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Product

CX3CL1, Soluble (h) (rec.) (FLAG)

Product Data

Synonyms : 

Fractalkine; Chemokine (C-X3-C Motif) Ligand 1; Neurotactin; SCYD1

Properties

Host : 

HEK 293 cells

Sequence :

The extracellular domain of human CX3CL1(Gln25-Arg339)(AAH01163.1) is fused at the C-terminus to the FLAG-tag.

Molecular Mass:

~50 KDa (SDS-PAGE)

 

 

Purity :

>90%by SDS-PAGE under reducing conditions. 

Endotoxin Content :

<60 EU/mg as determined by LAL test.

 


Shipping and Handling

Formulation : 

Lyophilized from 0.2μm-filtered solution in PBS. 

Reconstitution :

Reconstitute at 100μg/ml in sterile PBS.

Use / Stability :

 

Stable for at least 1 year after receipt when stored 

at -20°C. Working aliquots are stable for up to 3 months 

when stored at -20°C.

                        Avoid freeze/thaw cycles.

Documents
Description

CX3CL1 [Fractalkine] is expressed on TNF-α and IL-1 activated endothelial cells (ECs) and binds to CX3CR1. CX3CL1 can exist in 2 forms, as membrane-anchored or as a shed 95-kDa glycoprotein. The soluble CX3CL1 has potent chemoattractant activity for T cells and monocytes, and the cell surface bound protein, which is induced on activated primary endothelial cells, promotes strong adhesion of those leukocytes. CX3CL1 may play a role in regulating leukocyte adhesion and migration processes at the endothelium.

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