Manufacturer of Immune Regulation Proteins
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Product

HMGB1 (rat) (rec.) (His)

Product Data

Synonyms :  

High Mobility Group Protein B1HMG1, HMG3, SBP-1, amphoterin

Properties

Host : 

E. coli

Sequence : 

Rat HMGB1(NP_037095.1)(Arg24-Glu215),with a N-terminal 6-His tag.

Molecular Mass:

24KDa 

 

 

 

Purity :

≥90%by SDS-PAGE under reducing conditions. 

Endotoxin Content :

<0.1 EU/ug as determined by LAL test.

 


Shipping and Handling

Formulation : 

Lyophilized from 0.2μm-filtered solution in PBS. 

Reconstitution :

Reconstitute at 100μg/ml in sterile PBS.

Use / Stability :

 

Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months 

when stored at -20°C.

                        Avoid freeze/thaw cycles.

Documents
Description

HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-κB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac, CDC42 and NF-κB inducing localized innate immunity of damaged tissue, tissue regeneration by recruitment of stem cells and hemostasis by induction of tissue factor expression. HMGB1 is also causative agent of various diseases as it causes localized inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis.

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