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Product

CD54 [ICAM-1] (human):Fc (human) (rec.) (non-lytic)

Product Data

Synonyms :  

BB2CD54; P3.58

Properties

Host : 

CHO cell 

Sequence :

The extracellular domain of mouse CD54 (AAH08626.1)(Gln28-Asn485) is fused to the 

N-terminus of the Fc region of a mutant mouse IgG2a.

Molecular Mass: 

78KDa (monomer)

  

 

Purity :

>98%by SDS-PAGE under reducing conditions. 

Endotoxin Content :

<60 EU/mg as determined by LAL test.

Activity:

Shows the biological function of the CD54 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.


Documents
Description

Intercellular Adhesion Molecule-1 (ICAM-1, CD54) binds the leukocyte integrins LFA-1 and Mac1. CD54

expression is weak on leukocytes, epithelial and resting endothelial cells, as well as some other cell

types, but expression can be stimulated by IFN-γ, TNF-α, IL-1β and LPS. Soluble CD54 is found in a

biologically active form in serum, probably as a result of proteolytic cleavage from the cell surface, and is

elevated in patients with various inflammatory syndromes such as septic shock, LAD, cancer and

transplantation.

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