Manufacturer of Immune Regulation Proteins
Your Position : Home > Products > Others > CD54 [ICAM-1] (mouse):Fc (mouse) (rec.)(non-lytic)
Product

CD54 [ICAM-1] (mouse):Fc (mouse) (rec.)

Product Data

Synonyms :  

BB2CD54; P3.58

Properties

Host : 

CHO cell 

Sequence :

The extracellular domain of mouse CD54 (AAH08626.1)(Gln28-Asn485) is fused to the 

N-terminus of the Fc region of a mutant mouse IgG2a.

Molecular Mass: 

77KDa (monomer)

  

 

Purity :

>98%by SDS-PAGE under reducing conditions. 

Endotoxin Content :

<60 EU/mg as determined by LAL test.

Activity:

Measured by the ability of the immobilized protein to support the adhesion of 

PMA-stimulated HSB2 human peripheral blood acute lymphoblastic leukemia cells.

Shipping and Handling

Formulation : 

Lyophilized from 0.2μm-filtered solution in PBS.

Reconstitution :

Reconstitute at 100μg/ml in sterile PBS.

Use / Stability :

 

Stable for at least 1 year after receipt when stored 

at -20°C. Working aliquots are stable for up to 3 months 

when stored at -20°C.

                        Avoid freeze/thaw cycles.

Documents
Description

ICAM1 (Inter-Cellular Adhesion Molecule 1), also known as CD54, is a type of intercellular adhesion molecule constitutely present in low concentrations in the membranes of leukocytes and endothelial cells. As an endothelial and leukocyte-associated transmembrane protein, ICAM1 is well known for its importance in stabilizing cell-cell interactions and facilitating leukocyte endothelial transmigration.ICAM1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM1 possesses binding sites for a number of immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease.

Online Message