Manufacturer of Immune Regulation Proteins
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Product

Tim-1 (human):Fc (human) (rec.)

Product Data

Synonyms :  

TIM1; T Cell Membrane Protein 1 ; TIMD1; Hepatitis A Virus Cellular Receptor 1; 

T Cell Immunoglobulin and Mucin Domain-containing Protein 1; 

Properties

Host : 

CHO cell 

Sequence : 

The extracellular domain of human Tim-1 (NP_036338.2

 (Ser21-Gln295) is fused to the N-terminus of the Fc region of human IgG1.

Molecular Mass:

57 KDa (monomer)

 

 

 

Purity :

>98%by SDS-PAGE under reducing conditions 

Endotoxin Content :

<60 EU/mg as determined by LAL test.

 

 

Activity:

Measured by its ability to inhibit 

anti-CD3-induced proliferation of stimulated human T cells.

Shipping and Handling

Formulation : 

Lyophilized from 0.2μm-filtered solution in PBS.

Reconstitution :

Reconstitute at 100μg/ml in sterile PBS.

Use / Stability :

 

Stable for at least 1 year after receipt when stored 

at -20°C. Working aliquots are stable for up to 3 months 

when stored at -20°C.

                        Avoid freeze/thaw cycles.

Documents
Description

The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-1 (T cell-immunoglobulinmucin; also KIM-1 and HAVcr-1) is a 100 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules. There are two cytoplasmic alternate splice forms of TIM1. One is a long (359 aa) kidney form termed TIM-1b, and one is a short (334 aa) liver form termed TIM-1a. TIM-1, important for asthma and allergy, is preferentially expressed on T-helper 2 (Th2) cells and functions as a potent costimulatory molecule for T cell activation.

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