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Product

DcR3 (human):Fc (human) (rec.)

Product Data

Synonyms :  

TNFRSF6BTR6M68 

Properties

Host : 

CHO cells 

Sequence :

A soluble dimeric fusion protein consisting 

of the extracellular domain of human DcR3(O95407)

(Val24-His300) was fused to human IgG1 Fc.

 

Purity :

>98%(SDS-PAGE)

Endotoxin Content :

<60EU/mg as determined by LAL test

Formulation :

Lyophilized from 0.2μm-filtered solution in PBS.

Activity:

Measured by its ability to inhibit Fas 

Ligand-induced apoptosis of Jurkat human acute T cell leukemia cells. 

Shipping and Handling

Reconstitution : 

Reconstitute at 100μg/ml in sterile PBS.

Use / Stability:

 

Stable for at least 1 year after receipt when stored at -20°C. 

Working aliquots are stable for up to 3 months 

when stored at -20°C.

                        Avoid freeze/thaw cycles.

Documents
Description

Decoy receptor 3 (DcR3), also called TNFRSF6B, TR6 and M68, is a member of the TNF receptor superfamily. DcR3 shares sequence identity with OPG (31%), TNF RII (29%) and Fas (17%), and is expressed in a variety of different tissues and at high levels in many malignant tumors. Its known ligands include Fas ligand, homologous to lymphotoxin, showing inducible expression, and competing with HSV glycoprotein D for herpes virus entry mediator, a receptor expressed by T lymphocytes, TNF-like molecule 1A, and heparan sulfate proteoglycans. DcR3 modulate the functions of T cells, dendritic cells, and macrophages. DcR3/Fc fusion protein bound to human and mouse B cells and suppressed the activation of B cells. 

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