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Product

CD134 [OX40] (human):Fc (mouse) (rec.)

Product Data

Synonyms :  

TNFRSF4RP5-902P8.3ACT35; CD134; OX40; TXGP1L

Properties

Host : 

CHO cell 

Sequence :

The extracellular domain of human CD134 (NP_003318.1) (Leu29-Ala216) 

is fused to the N-terminus of the Fc region of mouse IgG2a.

Molecular Mass:

46KDa (monomer)

 

 

Purity :

>98%by SDS-PAGE under reducing conditions. 

Endotoxin Content :

<60 EU/mg as determined by LAL test.

 

Activity:

Measured by its binding ability in a functional ELISA.

Shipping and Handling

Formulation : 

Lyophilized from 0.2μm-filtered solution in PBS.

Reconstitution :

Reconstitute at 100μg/ml in sterile PBS.

Use / Stability :

 

Stable for at least 1 year after receipt when stored 

at -20°C. Working aliquots are stable for up to 3 months 

when stored at -20°C.

                        Avoid freeze/thaw cycles.

Documents
Description

TNFRSF4 (TNF receptor superfamily member 4), also well known as OX40, CD134, TXGP1L, is a T-cell activation antigen structurally belonging to a lymphocyte-specific subgroup of the nerve growth factor and tumor necrosis factor receptor superfamily, which also includes the T-cell antigen CD27, the B-cell antigen CD40, FAS antigen, and the T-cell activation antigen 4-1BB. The human OX40 protein is expressed only on activated CD4(+) T-blasts, and its ligand has been identified as gp34. Interactions between OX40 and its ligand in vivo are necessary for the differentiation of activated B-cells into highly immunoglobulin-producing cells, however not involved in other pathways of antigen-driven differentiation of B-cells such as development of memory cells in the germinal centers. In addition, The OX40 and gp34 system directly mediate adhesion of activated T-cells to vascular endothelial cells, and contributes to growth stimulation of the virus-infected T-cells as well.

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