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BMP-2 (human):Fc (human) (rec.) (non-lytic)

Product Data

Synonyms :  

BMP2; Bone Morphogenetic Protein 2


Host : 

CHO cell 

Sequence : 

The extracellular domain of human BMP-2 (NP_001191.1) (Arg289-Arg396) 

 is fused to the N-terminus of the Fc region of a mutant human IgG1.

Molecular Mass:

42 KDa (monomer)


Acts as a long lasting fusion protein which only binds to the receptor. 

Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins i

ncapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).




Purity :

>98%by SDS-PAGE under reducing conditions. 

Endotoxin Content :

<60 EU/mg as determined by LAL test.


Measured by its ability to induce alkaline phosphatase production 

by ATDC5 mouse chondrogenic cells.

Shipping and Handling

Formulation : 

Lyophilized from 0.2μm-filtered solution in PBS.

Reconstitution :

Reconstitute at 100μg/ml in sterile PBS.

Use / Stability :


Stable for at least 1 year after receipt when stored 

at -20°C. Working aliquots are stable for up to 3 months 

when stored at -20°C.

                        Avoid freeze/thaw cycles.


Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-β superfamily. It plays a dominant role in embryonic dorsalventral patterning, organogenesis, limb bud formation and bone formation and regeneration. BMP-2 signals through heterodimeric complexes composed of a type I receptor (Activin RI, BMP-RIA or BMP-RIB) and a type II receptor (BMP-RII or Activin RIIB). BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth and bone and cartilage repair. It induces ectopic bone formation or calcification by promoting osteogenic and chondrogenic differentiation in mesenchymal cells, stem cells and vascular smooth muscle cells. It also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells and is required for cardiac contractility.

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