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Product

TGFβ1 (mutant) (human):Fc (human) (rec.)

Product Data

Synonyms :  

Transforming Growth Factor beta-1; TGFB1; TGFB

Properties

Host : 

CHO cell 

Sequence : 

The extracellular domain of a mutant human TGFβ1 is fused to the 

 N-terminus of the Fc portion of human IgG4. Site-directed mutagenesis was used to change three cysteine codons 

into a serine codon that are located in the pro region of the 

TGF-β precursor at amino acid positions 33, 223, and 225.

Molecular Mass:

70 KDa (monomer)

 

 

 

Purity :

>98%by SDS-PAGE under reducing conditions. 

Endotoxin Content :

<60 EU/mg as determined by LAL test.

 

 

Activity:

Acts in conjunction with rapamycin to inhibit T cell proliferation 

and induce the denovo generation of Foxp3+ Treg in the periphery, 

and inhibiting IL6-mediated Th17 cell differentiation.

Shipping and Handling

Formulation : 

Lyophilized from 0.2μm-filtered solution in PBS.

Reconstitution :

Reconstitute at 100μg/ml in sterile PBS.

Use / Stability :

 

Stable for at least 1 year after receipt when stored 

at -20°C. Working aliquots are stable for up to 3 months 

when stored at -20°C.

                        Avoid freeze/thaw cycles.

Documents
Description

TGF-β1 (Transforming growth factor beta 1) is a polypeptide member of the transforming growth factor

beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the

control of cell growth, cell proliferation, cell differentiation and apoptosis. In humans, TGF-β1 is encoded by

the TGFB1 gene. TGF-β1 was first identified in human platelets as a protein with a molecular mass of 25

kaD with a potential role in wound healing. It was later characterized as a large protein precursor

(containing 390 aa) that was proteolytically processed to produce a mature peptide of 112 aa. TGF-β1

plays an important role in controlling the immune system, and shows different activities on different types

of cell, or cells at different developmental stages. Most immune cells (or leukocytes) secrete TGF-β1.

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