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Product

cEPO (human):Fc (human) (rec.)

Product Data

 

Synonyms :  

cEPO

Properties

Host : 

CHO cell 

Sequence :

The extracellular domain of human cEPO(NP_000790.2)(Pro30-Arg193) (Arg103Glu) is fused to the N-terminus of the Fc region of a human IgG1.

Molecular Mass:

44KDa (monomer)

 

 

Purity :

>98%by SDS-PAGE under reducing conditions 

Endotoxin Content :

<60 EU/mg as determined by LAL test.

Activity:

Measured by the dose-dependant stimulation of human megakaryoblastic leukemia cells.

Shipping and Handling

Formulation : 

Lyophilized from 0.2 μm-filtered solution in PBS.

Reconstitution :

Reconstitute at 100 μg/ml in sterile PBS.

Use / Stability :

 

Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

                        Avoid freeze/thaw cycles.

Documents
Description

Erythropoietin (EPO), a glycoprotein produced primarily by the kidney, is the principal factor that regulates erythropoiesis bystimulating the proliferation and differentiation of erythroid progenitor cells. The production of EPO by kidney cells is increased in response to hypoxia or anemia. Recombinant EPO has been approved for the treatment of anemia associated with chronic renal failure as well as for anemia of AZT treated AIDS patients. EPO (human):Fc (human) (rec.) is a long-acting version of EPO.

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