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TPO (human):Fc (human) (rec.) (non-lytic)

Product Data

Synonyms :  



Host : 

CHO cell 

Sequence :

The extracellular domain of human TPO(AAC37566.1)(Ser22-Gly353) 

is fused to the N-terminus of the Fc region of a mutant human IgG1. 

Molecular Mass:

62KDa (monomer)


Acts as a long lasting fusion protein which only binds to the receptor. 

Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins 

incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).


Purity :

>98%by SDS-PAGE under reducing conditions 

Endotoxin Content :

<60 EU/mg as determined by LAL test.



Measured in a cell proliferation assay.

Shipping and Handling

Formulation : 

Lyophilized from 0.2 μm-filtered solution in PBS.

Reconstitution :

Reconstitute at 100 μg/ml in sterile PBS.

Use / Stability :


Stable for at least 1 year after receipt when stored 

at -20°C. Working aliquots are stable for up to 3 months 

when stored at -20°C.

                        Avoid freeze/thaw cycles.


Thyroid peroxidase, also known as TPO, is a membrane-bound glycoprotein which belongs to the peroxidase family, XPO subfamily. It acts as an enzyme and plays a central role in thyroid gland function. Thyroid peroxidase/TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in thyroid peroxidase/TPO gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Thyroid peroxidase/TPO plays a key role in the thyroid hormone biosynthesis by catalysing both the iodination of tyrosyl residues and the coupling of iodotyrosyl residues in thyroglobulin to form precursors of the thyroid hormones T4 and T3. Defects in thyroid peroxidase/TPO are the cause of thyroid dyshormonogenesis 2A. A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.

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