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Product

FLT3L (human):Fc (mouse) (rec.)

Product Data

Synonyms :  

FLT3 Ligand; 

Properties

Host : 

CHO cell 

Sequence :

The extracellular domain of human FLT3L (AAI26294.1) (Thr27-Pro184) 

is fused to the N-terminus of the Fc region of mouse IgG2a.

Molecular Mass:

44KDa (monomer)

 

 

Purity :

>98%by SDS-PAGE under reducing conditions.

Endotoxin Content :

<60 EU/mg as determined by LAL test.

 

Activity:

Measured in a cell proliferation assay.

Shipping and Handling

Formulation : 

Lyophilized from 0.2μm-filtered solution in PBS.

Reconstitution :

Reconstitute at 100μg/ml in sterile PBS.

Use / Stability :

 

Stable for at least 1 year after receipt when stored 

at -20°C. Working aliquots are stable for up to 3 months 

when stored at -20°C.

                        Avoid freeze/thaw cycles.

Documents
Description

FLT3L, also known as flt3 ligand, acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It is a small molecule which also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3L is crucial for steady-state pDC and cDC development. It controls the development of DCs and is particularly important for plasmacytoid DCs and CD8-positive classical DCs and their CD103-positive tissue counterparts.

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