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Product

CX3CL1 (human):Fc (human) (rec.)

Product Data

Synonyms : 

Fractalkine; Chemokine (C-X3-C Motif) Ligand 1; Neurotactin; SCYD1

Properties

Host : 

CHO cell 

Sequence :

The extracellular domain of human CX3CL1 (AAH01163.1) (Gln25-Gly100) is fused to the N-terminus of the Fc region of human IgG1.

Molecular Mass:

35 KDa (monomer)

 

 

Purity :

>98%by SDS-PAGE under reducing conditions. 

Endotoxin Content :

<60 EU/mg as determined by LAL test.

Activity:

Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with mouse CX3CR1.

Shipping and Handling

Formulation : 

Lyophilized from 0.2μm-filtered solution in PBS. 

Reconstitution :

Reconstitute at 100μg/ml in sterile PBS.

Use / Stability :

 

Stable for at least 1 year after receipt when stored 

at -20°C. Working aliquots are stable for up to 3 months 

when stored at -20°C.

                        Avoid freeze/thaw cycles.

 

Documents
Description

CX3CL1 [Fractalkine] is expressed on TNF-α and IL-1 activated endothelial cells (ECs) and binds to CX3CR1. CX3CL1 can exist in 2 forms, as membrane-anchored or as a shed 95-kDa glycoprotein. The soluble CX3CL1 has potent chemoattractant activity for T cells and monocytes, and the cell surface bound protein, which is induced on activated primary endothelial cells, promotes strong adhesion of those leukocytes. CX3CL1 may play a role in regulating leukocyte adhesion and migration processes at the endothelium.

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