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Product

CCL4 (human):Fc (human) (rec.)

Product Data

Synonyms : 

C-C Motif Chemokine 4; Lymphocyte Activation Gene 1 Protein; 

LAG-1; Macrophage Inflammatory Protein 1β; 

MIP-1β; T Cell Activation Protein 2; ACT-2; 

Small-inducible Cytokine A4; PAT 744; Protein H400

Properties

Host : 

CHO cell 

Sequence : 

The extracellular domain of human CCL4 (AAI04227.1) 

(Ala24-Asn92) is fused to the 

N-terminus of the Fc portion of human IgG1.

Molecular Mass:

34 KDa (monomer)

 

 

Purity :

>98%by SDS-PAGE under reducing conditions. 

Endotoxin Content :

<60EU/mg as determined by LAL test.

 

 

Activity:

Measured by its ability to chemoattract BaF3 mouse 

pro-B cells transfected with human CCR5.

Shipping and Handling

Formulation :

Lyophilized from 0.2μm-filtered solution in PBS.

Reconstitution :

Reconstitute at 100μg/ml in sterile PBS.

Use / Stability :

 

Stable for at least 1 year after receipt when stored 

at -20°C. Working aliquots are stable for up to 3 months 

when stored at -20°C.

                        Avoid freeze/thaw cycles.

Documents
Description

CCL4, (C-C motif chemokine 4; macrophage inflammatory protein 1β) is a chemokine secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells and pulmonary smooth cells. CCL4 attracts a variety of immune cells to sites of microbial infection as well as to pathologic inflammation, such as allergic asthma and ischemic myocardium. Full-length and truncated CCL4 exert biological activity through the receptor CCR5. The truncated form of CCL4 interacts additionally with CCR1 and CCR2b. The ability of CCL4 to bind CCR5 inhibits the cellular entry of M-tropic HIV. Both CCL4 forms block HIV-1 infection of T cells by inducing the downregulation of CCR5.

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