Manufacturer of Immune Regulation Proteins
Your Position : Home > Products > Chemokines > CCL5 (human) (rec.) (His)
Product

CCL5 (human):Fc (human) (rec.)

Product Data

Synonyms : 

D17S136E; SCYA5CCL5; D17S136E; MGC17164; RANTES; SCYA5; SISd; TCP228

Properties

Host : 

E. coli

Sequence :

Human CCL5 (AAH08600)(Ser24-Ser91), with a C-terminal 6-His tag

Molecular Mass:

12KDa (SDS-PAGE)

 

Purity :

>98%by SDS-PAGE under reducing conditions. 

Endotoxin Content :

<0.1 EU/ug as determined by LAL test.

 

Shipping and Handling

Formulation :

Lyophilized from 0.2μm-filtered solution in PBS.

Reconstitution :

Reconstitute at 100μg/ml in sterile PBS.

Use / Stability :

 

Stable for at least 1 year after receipt when stored 

at -20°C. Working aliquots are stable for up to 3 months 

when stored at -20°C.

                        Avoid freeze/thaw cycles.

Documents
Description

Chemokine (C-C motif) ligand 5, also known as CCL5 and RANTES (acronym for Regulated upon Activation, Normal T cell Expressed and presumably Secreted), is an 8 kDa protein classified as a member of the β (C-C) chemokine subfamily of proinflammatory cytokines. CCL5 is chemotactic for T cells,eosinophils, and basophils, and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines that are released by T cells, CCL5 induces the proliferation and activation of certain natural killer (NK) cells. It is also an HIV-suppressive factor released from CD8+ T cells and has been shown to interact with CCR3, CCR5, and CCR1. Fractalkine (also known as CX3CL1) is one of two known transmembrane chemokines, and contains a chemokine domain tethered on a long mucin-like stalk within the ECD. Fractalkine binds with high affinity to CX3CR1 and mediates the tight binding of leukocytes expressing CX3CR1 independently of G protein activation. The chemokine domain of human Fractalkine is replaced by human RANTES in the purified RANTES/mucin-like stalk chimera.

Online Message