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Product

CCL22 (human):Fc (human) (rec.)

Product Data

Synonyms : 

C-C Motif Chemokine 22; CC Chemokine 

STCP-1; Stimulated T Cell Chemotactic Protein 1; MDC; 

Macrophage-derived Chemokine; Small-inducible Cytokine A22  

Properties

Host : 

CHO cell 

Sequence :

The extracellular domain of human CCL22 (AAH27952.1)

(Gly25-Gln93) is fused to the 

N-terminus of the Fc region of human IgG1.

Molecular Mass:

34 KDa (monomer)

 

 

Purity :

>98%by SDS-PAGE under reducing conditions. 

Endotoxin Content :

<60 EU/mg as determined by LAL test.

Activity:

Measured by by a chemotaxis bioassay using human T-lymphocytes

 

Shipping and Handling

Formulation :

Lyophilized from 0.2μm-filtered solution in PBS.

Reconstitution :

Reconstitute at 100μg/ml in sterile PBS.

Use / Stability :

 

Stable for at least 1 year after receipt when stored 

at -20°C. Working aliquots are stable for up to 3 months 

when stored at -20°C.

                        Avoid freeze/thaw cycles.

Documents
Description

CCL22, also named stimulated T cell chemotactic protein (STCP1), is a CC chemokine initially isolated from clones of monocyte-derived macrophages and binds to the receptor CCR4. Human CCL22 is highly expressed in macrophage and in monocyte-derived dendritic cells and thymus. It is also found in lymph node, appendix, activated monocytes, resting and activated macrophages. May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. CCL22 has been shown to induce chemotaxis or Ca2+ mobilization in dendritic cells, IL-2 activated NK cells and activated T lymphocytes.

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