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Product

CCL22 (mouse):Fc (mouse) (rec.)

Product Data

Synonyms : 

C-C Motif Chemokine 22; CC Chemokine 

STCP-1; Stimulated T Cell Chemotactic Protein 1; STCP1; MDC; 

Macrophage-derived Chemokine; Small-inducible Cytokine A22 

Properties

Host : 

CHO cell 

Sequence :

The extracellular domain of mouse CCL22 (NP_033163.1)(Gly25-Ser92) is fused to the N-terminus of the Fc portion of mouse IgG2a.

Molecular Mass:

34 KDa

 

 

Purity :

≥98%by SDS-PAGE under reducing conditions. 

Endotoxin Content :

<60 EU/mg as determined by LAL test.

 

Activity:

Measured by a chemotaxis bioassay using human activated lymphocytes 

Shipping and Handling

Formulation :

Lyophilized from 0.2μm-filtered solution in PBS.

Reconstitution :

Reconstitute at 100μg/ml in sterile PBS.

Use / Stability :

 

Stable for at least 1 year after receipt when stored 

at -20°C. Working aliquots are stable for up to 3 months 

when stored at -20°C.

                        Avoid freeze/thaw cycles.

Documents
Description

CCL22 (C-C Motif Chemokine 22; Stimulated T cell chemotactic protein; STCP1) is a CC chemokine initially isolated from clones of monocyte-derived macrophages and binds to the receptor CCR4. Human CCL22 is highly expressed in macrophage and in monocyte-derived dendritic cells and thymus. It is also found in lymph node, appendix, activated monocytes, resting and activated macrophages. May play a role in the trafficking of activated/effector T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. CCL22 has been shown to induce chemotaxis or Ca2+ mobilization in dendritic cells, IL-2 activated NK cells and activated T lymphocytes.

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