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Product

CCL24 (human):Fc (human) (rec.)

Product Data

Synonyms : 

Eotaxin-2; 

C-C Motif Chemokine 24; Eosinophil Chemotactic Protein 2; 

Myeloid Progenitor Inhibitory Factor 2; MPIF-2; 

Small-inducible Cytokine A24; CKβ6   

Properties

Host : 

CHO cell 

Sequence : 

The extracellular domain of human CCL24 (AAH69391.1) 

(Val27-Cys119) is fused to the 

N-terminus of the Fc portion of human IgG1.

Molecular Mass:

3KDa (monomer)

 

 

Purity :

>98%by SDS-PAGE under reducing conditions. 

Endotoxin Content :

<60 EU/mg as determined by LAL test.

 

 

Activity:

Measured by its ability to chemoattract Y3 rat myeloid cells transfected with human CCR3.

Shipping and Handling

Formulation : 

Lyophilized from 0.2μm-filtered solution in PBS. 

Reconstitution :

Reconstitute at 100μg/ml in sterile PBS.

Use / Stability :

 

Stable for at least 1 year after receipt when stored 

at -20°C. Working aliquots are stable for up to 3 months 

when stored at -20°C.

                        Avoid freeze/thaw cycles.

 


Documents
Description

CCL24 (eotaxin-2) has been shown to induce chemotaxis of eosinophils, basophils and resting T lymphocytes but not monocytes and activated T lymphocytes. CCL24 is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. CCL24 interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils. Elevated levels of CCL24 has been seen in patients with aspirin-exacerbated respiratory disease(AERD), such as asthma.

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