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Product

B7-H4 (mouse):Fc (mouse) (rec.)

Product Data

Synonyms : 

V-set Domain-containing T Cell Activation Inhibitor 1; VTCN1; Immune Costimulatory 

Protein B7-H4; T Cell Costimulatory Molecule B7x

Properties

Host : 

CHO cells

Sequence :

The extracellular domain of mouse B7-H4(NP_848709.2)(Phe29-Pro258) is fused to the N-terminus of the Fc region of mouse IgG2a. 

Molecular Mass:

54 KDa (monomer)

Purity :

≥98%by SDS-PAGE under reducing conditions. 

Endotoxin Content :

<60 EU/mg as determined by LAL test.

 

 

Activity:

Measured by its ability to inhibit 

anti-CD3-induced proliferation of stimulated human T cells. 

Shipping and Handling

Formulation : 

Lyophilized from 0.2μm-filtered solution in PBS.

Reconstitution :

Reconstitute at 100μg/ml in sterile PBS.

Use / Stability :

 

Stable for at least 1 year after receipt when stored 

at -20°C. Working aliquots are stable for up to 3 months 

when stored at -20°C.

                        Avoid freeze/thaw cycles.


Documents
Description

B7H4 is a B7 family member that negatively regulates T cell immunity by inhibiting of T cell proliferation, cytokine production, and cell cycle progression. In vitro, B7H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production, and generation of alloreactive cytotoxic T-cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance.

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