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Product

IL-6 (human):Fc (human) (rec.)

Product Data

Synonyms : 

Interleukin-6; B Cell Stimulatory Factor 2; BSF-2; CTL Differentiation Factor; CDF; Interferon β2; IFN-β2

Properties

Host : 

CHO cell 

Sequence :

The extracellular domain of human IL-6 (NP_000591.1)(Val30-Met212) is fused to the N-terminus of the Fc region of human IgG1.

Molecular Mass:

47 KDa (monomer)

 

Purity :

>98%by SDS-PAGE under reducing conditions. 

Endotoxin Content :

<60EU/mg as determined by LAL test.

 

 

Activity:

Measured by the dose-dependent stimulation of the proliferation of IL-6 dependent mouse 7TD1 cells .

 

 

 
Shipping and Handling

Formulation :

Lyophilized from 0.2μm-filtered solution in PBS.

Reconstitution :

Reconstitute at 100μg/ml in sterile PBS.

Use / Stability :

 

Stable for at least 1 year after receipt when stored 

at -20°C. Working aliquots are stable for up to 3 months 

when stored at -20°C.

                        Avoid freeze/thaw cycles.

Documents
Description

Interleukin 6 (IL-6) is a pleiotropic α-helical cytokine that plays important roles in acute phase reactions, inflammation,hematopoiesis, bone metabolism and cancer progression. IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. It is secreted by multiple cell types as a 22kDa-28kDa phosphorylated and variably glycosylated molecule. IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6R) and a signal transducing subunit (gp130). IL-6 is a key factor for the growth of plasma cells.

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