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Product

IL-6R (human):Fc (mouse) (rec.)

Product Data

Synonyms : 

D126; gp80; Interleukin-6 receptor subunit alpha; IL6RA

Properties

Host : 

CHO cell

Sequence :

The extracellular domain of human IL-6R (NP_000556.1)(Leu20-Ser359) is fused to the N-terminus of the Fc region of mouse IgG2a.

Molecular Mass:

68 KDa (monomer)

Purity :

>98%by SDS-PAGE under reducing conditions. 

Endotoxin Content :

<60 EU/mg as determined by LAL test.

 

 

Activity:

Measured by its ability to enhance the IL-6 activity on M1 mouse myeloid leukemia cells.

Shipping and Handling

Formulation :

Lyophilized from 0.2μm-filtered solution in PBS.

Reconstitution :

Reconstitute at 100μg/ml in sterile PBS.

Use / Stability :

 

Stable for at least 1 year after receipt when stored 

at -20°C. Working aliquots are stable for up to 3 months 

when stored at -20°C.

                        Avoid freeze/thaw cycles.

Documents
Description

Interleukin-6 (IL-6) is a multifunctional factor, which exerts its activities through binding to a highaffinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6Rα) and a signal transducing component of 130 kDa (gp130) that does not bind IL-6 by itself, but is required for highaffinity binding of IL-6 by the complex. A soluble form of the IL-6Rα has been found in the urine of healthy adult humans.

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